This month, we are proud to highlight the continued scientific contributions William Sivitz, MD, a foundational member of the Fraternal Order of Eagles Diabetes Research Center and a cornerstone of the University of Iowa’s endocrinology and diabetes research community since 1987.

Dr. Sivitz, now emeritus faculty, remains actively involved in research and continues to publish impactful work. His latest study entitled “Detection of liver mitochondrial oxaloacetate by NMR spectroscopy and membrane potential-dependent accumulation” was recently published in the FASEB Journal. This innovative research utilizes nuclear magnetic resonance (NMR) spectroscopy to investigate how oxaloacetate—a key metabolic intermediate—is detected and regulated within liver mitochondria, often known as the “powerhouse” of the cell. His findings shed light on the role of mitochondrial membrane potential in oxaloacetate accumulation, offering deeper insight into cellular energy metabolism and its relevance to metabolic diseases such as diabetes and obesity.

Dr. Sivitz’s career exemplifies a powerful blend of clinical care and basic science. As a practicing endocrinologist for decades, his work has always been grounded in improving patient outcomes. His contributions to two of the most influential multicenter diabetes trials—the Diabetes Control and Complications Trial (DCCT) and the Glycemia Reduction Approaches in Diabetes (GRADE) study—have helped shape the clinical standards used to treat people with diabetes today.

Throughout his career, Dr. Sivitz has been a national leader in studying how our cells produce energy and how this process can go wrong in diseases like diabetes. He has focused especially on mitochondria and how their function and stress levels affect the body’s overall health. His research has helped us better understand how small changes at the cellular level can lead to bigger problems in metabolism and disease.

As a founding member of the FOEDRC, Dr. Sivitz has played an essential role in building the research culture that defines our Center. His curiosity, rigor, and mentorship continue to inspire colleagues and trainees alike. We are deeply grateful for his ongoing presence and leadership in our scientific community.